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Download 2008 Amendments to the National Academies' Guidelines for by National Research Council, Institute of Medicine, Board on PDF

By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee

In 2005, the nationwide Academies published the record directions for Human Embryonic Stem mobile learn, which provided a typical set of moral criteria for a box that, as a result of absence of finished federal investment, used to be missing nationwide criteria for research.

In order to maintain the tips brand new, given the swift speed of clinical advancements within the box of stem mobilephone examine, the Human Embryonic Stem mobilephone examine Advisory Committee was once confirmed in 2006 with aid from The Ellison clinical beginning, The Greenwall starting place, and the Howard Hughes scientific Institute.

As it did in 2007, the Committee pointed out concerns that warranted revision, and this publication addresses these matters in a moment set of amendments. most significantly, this publication addresses new clinical advancements in reprogramming of somatic cells to pluripotency via including a brand new part and revising different proper sections of the Guidelines.

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Extra resources for 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

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210, (iii) r esearch using human pluripotent stem (hPS) cells derived from non-embryonic sources, such as spermatogonial stem cells and “induced pluripotent” stem cells derived from somatic cells by introduction of genes or otherwise (so-called iPS cells), as well as other pluripotent cells yet to be developed. Recommendations as to which guidelines apply to other hPS cells are collected in Section 7 below. Institutions and investigators conducting research using such materials with adult and fetal stem cells should also consider which individual provisions of these guidelines are relevant to their research.

New or modified wording is indicated by underlining, deleted text by strikeout. 39 40 Appendix B Chimera—An organism composed of cells derived from at least two genetically different cell types. The cells could be from the same or separate species. Differentiation—The process whereby an unspecialized early embryonic cell acquires the features of a specialized cell, such as a heart, liver, or muscle cell. DNA—Deoxyribonucleic acid, a chemical found primarily in the nucleus of cells. DNA carries the instructions for making all the structures and materials the body needs to function.

2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920. 0­ INTRODUCTION In this chapter we collect all the recommendations made throughout the report and translate them into a series of formal guidelines. These guidelines focus on the derivation, procurement, banking, and use of human embryonic stem (hES) cell lines. They provide an oversight process that will help to ensure that research with hES cells is conducted in a responsible and ethically sensitive manner and in compliance with all regulatory requirements pertaining to biomedical research in general.

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