'All of Nichol’s paintings is stamped through his wish to create texts which are carrying out themselves in addition to in context, and to take advantage of oblique structural and textual units to hold that means. In The Martyrology alternative ways of talking testify to a trip via alternative ways of being. Language is either the poet’s teacher and, via its a number of diversifications, the dominant 'image' of the poem. The [nine] books of The Martyrology rfile a poet’s quest for perception into himself and his writing via scrupulous recognition to the messages hidden within the morphology of his personal speech.’ – Frank Davey
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Extra resources for Ad Sanctos (The Martyrology, Book 9)
J Immunol 1994; 152:3913-3924. 57. Kondo A, Sidney J, Southwood S et al. Two distinct HLA-A*0101-specific submotifs illustrate alternative peptide binding modes. Immunogenet 1997; 45:249-258. 58. Southwood S, Sidney J, Kondo A et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol 1998; 160:3363-3373. 59. Geluk A, van Meijgaarden KE, Southwood S et al. HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs. J Immunol 1994; 152:5742-5748.
P53 We have also extended our approach of vaccination with tumor specific antigens to the p53 gene. Wild type p53 ordinarily acts as a tumor suppresser gene. However, once p53 becomes mutated, it is no longer able to act as a tumor suppresser gene. Thus if additional mutations occur, p53 is no longer able to block the full transformation into a malignant cancer cell. p53 mutations are very common, occurring in approximately half of human cancers. These mutations do not occur at a limited number of sites as they do in ras, but do tend to cluster at exons five through eight.
Com. 18 Peptide-Based Cancer Vaccines the body’s immune system in a variety of ways. 12-14 Antigen may be presented to T cells through the class I or class II pathway. Cytotoxic T lymphocytes generated through the interaction of T cells with the class I system are thought to be the major mechanism by which cancer cells and intracellular pathogens are eliminated. Antigens presented to the class I pathway are displayed in the form of an eight to ten amino acid peptide within the groove of the class I molecule.