By Jiben Roy
This textbook is written as a unified method of a number of themes, starting from drug discovery to production, suggestions and know-how, rules and advertising. the foremost subject matter of the booklet is prescription drugs - what each scholar of pharmaceutical sciences should still be aware of: from the energetic pharmaceutical elements to the practise of assorted dosage varieties besides the suitable chemistry, this e-book makes prescribed drugs proper to undergraduate scholars of pharmacy and pharmaceutical sciences.
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Extra info for An introduction to pharmaceutical sciences: Production, chemistry, techniques and technology
1951–1999 1998: Viagra®(sildenafil citrate) for erectile dysfunction; 1995: Cardura®(doxazosin mesylate) to treat benign prostate hyperplasia (BPH); 1992: Zoloft®(sertraline hydrochloride) for treatment of depression, Norvasc®(amlodipinebe sylate) for control of angina and hypertension, and Zithromax®(azithromycin) for respiratory and skin infections; 1990: Diflucan®(flucona zole), a powerful antifungal; 1989: Procardia®XL (nifedipine) extended-release tablets; 1986: Unasyn®(ampicillin sulbactam), an injectable antibiotic; 1984: Glucotrol®(glipizide), for diabetes; 1980: Feldene®(piroxicam) anti-inflammatory medications; 1976: Minipress®(prazosin HCI) for the control of high blood pressure; 1967: Vibramycin®(doxycycline hyclate), once-a-day broad-spectrum antibiotic.
21). 6 Pharmaceutical research and development The pharmaceutical industry is research-based. If there were no research, there would be no new molecular entity. 22 shows the expenditure of US biopharmaceutical companies on R&D from 2004 to 2009. As a result, the US FDA approved 34 new drugs and biologics in 2009 and more than 2,000 medicines are in the development pipeline. 3 billion on R&D in 2008,19 which is almost 30% of total pharmaceutical sales. This was more than £10 million per day, and on average the investment in pharmaceutical R&D has been greater than investments on R&D of other British manufacturing sectors.
2 shows the steps involved in discovering ‘cure all’, which also apply to discovering other medicines. The book will also help students understand the exciting career opportunities in the pharmaceutical industry. This book is intended for 2nd to 4th year undergraduate students or postgraduate students who have already taken organic chemistry. Topics include: •• •• •• •• •• •• •• •• •• possibilities of having a career in this industry the manufacturing of APIs different dosage forms what bulk drugs and formulated drugs are critical factors in the development of pharmaceutical formulations in relation to the principles of chemistry good manufacturing practice quality assurance interdisciplinary science networks – the usefulness of teamwork in science the regulation of pharmaceuticals by government agencies.