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By David A Gewirtz (Editor), Shawn Edan Holt (Editor), Steven Grant (Editor)

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Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999; 21(1):99–102. 254. Kaufmann SH, Gores GJ. Apoptosis in cancer: cause and cure. Bioessays 2000; 22:1007–17. 255. Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome C from mitochondria. Mol Cell Biol 1999; 19(8):5800–10. 256. Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003; 22:9030–40. 257. Michalak EM, Villunger A, Erlacher M, Strasser A.

Oncogene 1991; 6:1915–22. 238. Evan GI, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69(1): 119–28. 239. Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998; 12:2424–33. 240. Egle A, Harris AW, Bouillet P, Cory S. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 2004; 101:6164–9. 241. Eischen CM, Woo D, Roussel MF, Cleveland JL.

74. Coultas L, Strasser A. The role of the Bcl-2 protein family in cancer. Semin Cancer Biol 2003; 13(2):115–23. 75. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1998; 335(6189):440–2. 76. Hockenbery DM, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348:334–6. 77. Puthalakath H, Strasser A. Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins.

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