By Stephen C. Rubin (Editor), Gregory P. Sutton (Editor)
Univ. of Pennsylvania, Philadelphia. keeps its association into sections at the uncomplicated technology, histopathology, and medical features of ovarian melanoma. Chapters were rewritten and contain the dramatic advances during this quarter because the earlier version, c1993, used to be written. New facts on screening and administration of early degree illness is incorporated. DNLM: Ovarian Neoplasms.
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Extra resources for Ovarian Cancer, 2nd Edition
The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med 1994;96:516â 520. 48. Aarnio M, Mecklin JP, Aaltonen LA, et al. Life-time risk of different cancers in the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 1995;64:430â 433. 49. Vasen HF, Wijnen JT, Menko FH, et al. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 1996;110:1020â 1027. 50. Dunlop MG, Farrington SM, Carothers AD, et al.
98. Coene E, Van Oostveldt P, Willems K, et al. BRCA1 is localized in cytoplasmic tube-like invaginations in 39 40 the nucleus. Nat Genet 1997;16:122â 124. 99. Wilson CA, Ramos L, Villasenor MR, et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999;21:236â 240. 100. Koonin EV, Altschul S, Bork P. BRCA1 protein products: functional motifs. Nat Genet 1996;13:266â 268. 101. Chapman MS, Verma IM. Transcriptional activation by BRCA1. Nature 1996;382:678â 679.
Studies of the role of Brca2 in mouse development indicate that loss of the protein confers radiation hypersensitivity, consistent with its interaction with the Rad51 protein involved in repair of double-strand DNA breaks (138). 15 proteins may thus be involved in the same biochemical pathway, mediated by RAD51, regulating genomic integrity (118,138,139). Additional studies with the Brca2 nullizygous mouse model provide further data implicating Brca2 in the response to DNA damage. The Brca2 knockout mouse also displays an embryonic lethal phenotype, indicating a critical role for Brca2 in cellular proliferation during embryogenesis (124,138,140).