Download Protein-Lipid Interactions: From Membrane Domains to by Lukas K. Tamm PDF

By Lukas K. Tamm

In 17 contributions via top examine teams, this primary finished instruction manual within the box covers the interactions among proteins and lipids that make the cloth of organic membranes from each perspective. It examines the suitable hermodynamic and structural matters from a uncomplicated technological know-how viewpoint, and is going directly to talk about biochemical and telephone organic strategies. The publication covers actual rules in addition to mechanisms of membrane fusion and fission. also, chapters on bilayer constitution and protein-lipid interactions in addition to on how proteins form lipids and vice versa, membrane penetration via pollutants, protein sorting, and allosteric rules of sign transduction throughout membranes make this a useful details resource for researchers in academia and undefined.

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Natl. Acad. Sci. USA 1995; 92(20): 9407–9411. , Molecular characterization of caveolin association with the Golgi complex: identification of a cisGolgi targeting domain in the caveolin molecule. J. Cell Biol. 1999; 145(7): 1443–1459. , Multiple domains in caveolin-1 control its intracellular traffic. J. Cell Biol. 2000; 148(1): 17–28. Scherer, P. , Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. USA 1996; 93(1): 131–135. , Caveolin-2 localizes to the Golgi complex but redistributes to plasma membrane, caveolae, and rafts when coexpressed with caveolin-1.

L. Keller, Seeing spots: Complex phase behavior in simple membranes. Biochim. Biophys. Acta 2005; in press. Hammond, A. , Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes. Proc. Natl. Acad. Sci. USA 2005; 102(18): 6320–6325. 68 Herzlinger, D. A. and G. K. Ojakian, Stud- 69 70 71 72 73 74 75 76 77 78 79 ies on the development and maintenance of epithelial cell surface polarity with monoclonal antibodies. J. Cell Biol. 1984; 98(5): 1777–1787.

The membrane curvature C is roughly constant over the deformed area S which has radius of curvature (the radius of the circle passing through the cap) 1/C, as shown. Inset: the bilayer structure of a lipid membrane. 3 Caveolae as Invaginated Lipid Rafts some anchoring sites upon cell deformation and membrane extension is a major component of the energy cost of such deformations. In particular, cytoskeleton anchoring can account for up to 75 % of the measured tension of cell membranes [15]. Here, we adopt the philosophy that the cytoskeleton acts to maintain the plasma membrane under tension, but does not exert direct forces to pull flaskshaped invaginations from the membrane.

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